Synthesis of salicylic acid. Salicylic Acid 2022-12-24

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Salicylic acid is a widely used organic compound that has a variety of applications in the pharmaceutical and personal care industries. It is a white, crystalline solid that is derived from the metabolism of salicin, which is found in plants such as willow and meadowsweet. Salicylic acid has anti-inflammatory and analgesic properties, making it an effective treatment for a range of conditions such as acne, dandruff, and warts. It is also used as a preservative and a pH adjuster in a variety of personal care products.

There are several methods for synthesizing salicylic acid, each with its own set of advantages and disadvantages. One common method is the Kolbe-Schmitt reaction, which involves the electrochemical reduction of phenol using an electrolytic cell. This method is efficient and cost-effective, but it produces a low yield of salicylic acid and requires the use of hazardous chemicals such as concentrated sulfuric acid.

Another method for synthesizing salicylic acid is the Hock reaction, which involves the treatment of sodium phenoxide with carbon dioxide and water. This method is less hazardous and produces a higher yield of salicylic acid, but it requires the use of specialized equipment such as a high-pressure reactor.

A third method for synthesizing salicylic acid is the hydrolysis of acetylsalicylic acid, also known as aspirin. This method is simple and cost-effective, but it produces a lower yield of salicylic acid compared to the other methods.

Regardless of the method used, the synthesis of salicylic acid requires careful control of the reaction conditions to ensure that the desired product is obtained in high purity. Impurities can affect the physical and chemical properties of the final product, which can impact its effectiveness and safety.

In conclusion, salicylic acid is an important organic compound that has a wide range of applications in the pharmaceutical and personal care industries. There are several methods for synthesizing salicylic acid, each with its own set of advantages and disadvantages. The selection of a synthesis method depends on the desired yield, cost, and safety considerations. Regardless of the method used, it is important to carefully control the reaction conditions to ensure that the final product is of high purity.

Synthesis of Salicylic Acid and Potentiometric Determination of Its Purity and Dissociation Constant

synthesis of salicylic acid

These groups cause the acid to be an irritating substance that burns the delicate lining of the mouth, throat, and stomach, hence its esterification to acetylsalicylic acid or aspirin, before ingestion as analgesic Reed College, 2009. When the base is added, HA reacts with the hydroxide ion OH— according to the Eq. Heat the water to its boiling point to dissolve all the salicylic acid, then let it cool to room temperature and filter the nice needle shaped crystals. The pH 11 of sodium hydroxide avoids liquid flooding that occurs when using ammonium hydroxide. All chemicals were kept inside the fume hood at all times. Oil of wintergreen is 98% methyl 2-hydroxybenzoate and is what I used as my starting chemical.

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What happens when acetic anhydride is added to salicylic acid?

synthesis of salicylic acid

At 15°C, the solubility is only 0. How do you determine the melting point of aspirin? The The An extract of willow bark, called Spiraea ulmaria by German researchers in 1839. After cooling to room temperature, 1. Sylva, NC: ; cited in Moerman D. Therefore, one has a buffer solution comprised of salicylic acid and salicylate. The literature value of pure salicylic acid is 159°C. The melting point of the salicylic acid derived from benzene mixed with the experimental product was 155-162°C.

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CHE201 Lab 4 Report

synthesis of salicylic acid

The product of the reaction, salicylic acid was a white precipitate, the starting material, methyl salicylate was a liquid. Filter the solution through one or two coffee filters, squeezing the filters into the filtrate afterward to recover some of the liquid. The diameter of the fibres was around 15±3 μm. REQUIREMENTS Chemicals: Methyl- salicylate Sulfuric acid 6M Sodium hydroxide 6M Apparatus: 200 ml beaker 125 ml Erlenmeyer flask Filtration apparatus 200 ml reflux apparatus PROCEDURE 3 ml methyl-salicylate density — 1. Methyl salicylate is also a botanical extract. The solution is then refluxed which means that the solution will be boiled in a base, then condensed in a condenser.

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Synthesis of salicylic acid from alkyl salicylate

synthesis of salicylic acid

Methyl salicylate and the volatile methyl acetate are formed at the same time, the latter being removed by evaporation when reaction crude is processed. A white solid should form. The endpoint is a point during titration wherein an observable change signals that the amount of titrant added is chemically equivalent with that of the analyte. Statistical Analysis of the Results Range Standard Deviation %purity 15. The information offered in the Material Safety Data Sheet MSDS should be consulted.

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Synthesis of Acetylsalicylic Acid

synthesis of salicylic acid

This could be reason as for why the there was a great temperature difference in the melting points of aspirin, The solubility of aspirin in water varies with temperature. The resulting solution was gently mixed. CN107434768B - Synthesis method of 5-nitro salicylic acid - Google Patents CN107434768B - Synthesis method of 5-nitro salicylic acid - Google Patents Synthesis method of 5-nitro salicylic acid Info Publication number CN107434768B CN107434768B CN201610354726. There was no way to tell weather these had been measured out correctly. This could have affected the purity of the Aspirin formed at the end.

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Synthesis of Salicylic Acid

synthesis of salicylic acid

The effects of high-speed melt spinning and spin drawing on the structure and the resulting properties of bacterially generated poly 3-hydroxybutyrate PHB fibres were investigated by Schmack et al. An ester is a compound that is formed when an acid containing the COOH group reacts with an alcohol a compound containing an -OH group. Once the aspirin has been produced in the laboratory, its yield will be measured. Melting point helped to characterize organic compound and to assure its purity. Mukopadhyay, in Technical Textile Yarns, 2010 16. The mixture was then allowed to cool slowly.

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Salicylic acid

synthesis of salicylic acid

Therefore you should get a temperature range of the aspirin Hazard and Risk Analysis: Included with the report is the MSDS data sheet. This is due to the acid having more than 6 carbons increasing its non-polarity, although it has oxygen that can form hydrogen bonds with water McMurry, 2004. Add the powdered aspirin tablets to your choice of solvent. It is the major constituent of oil of wintergreen, which makes up over 90% of the essential oil from the wintergreen plant. This will be done by subtracting the mass of the dry weight by the mass of the beaker. The aspirin collected will then be purified by recrystallization.

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Synthesis of Salicylic Acid from Wintergreen Oil

synthesis of salicylic acid

Record the temperature where the melting point is first observed and when it becomes a liquid completely. Place this beaker on top of a hot plate or other heating source, and place a round-bottom flask full of ice water on top of the beaker. Therefore, if you add FeCl3 to an aspirin sample and you see a purple color, it means that there is still some salicylic acid present and the sample is impure. The melting point of an organic solid can be determined by introducing a tiny amount into a small capillary tube, attaching this to the stem of a thermometer centred in a heating bath, heating the bath slowly, and observing the temperatures at which melting begins and is complete. In fact, aromatic hydroxylation in animal models of diabetes mellitus was demonstrated using Phe where the degree of oxidation was correlated with levels of lipid peroxidation and glycooxidation. Statistical analysis of the results shows the following results: Table 1.

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Synthesis of salicylic acid

synthesis of salicylic acid

This was calculated using the following formula. . The ultra-homogenization promoted an excellent dispersion of the zeolite particles and CS chain without the formation of agglomerates, meaning that the homogenization was proper for obtaining composite films. There were differences in peak intensity and width, but overall, the functional groups remained the same. In the experiment, the electrode was also not lowered while the bar was spinning as air bubbles would adhere on its surface causing an error in the measurement of pH.

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CN107434768B

synthesis of salicylic acid

To complete the precipitation, 0. In the formation of methyl salicylate oil of wintergreen , salicylic acid and methanol were reacted together in the presence of the same acid catalyst, sulfuric acid. Using resting human neutrophils, d-Phe hydroxylation did not occur but l-Phe was converted to p-Tyr. The fibre structures formed during these processes were fibril-like, as shown by the atomic force microscopy images. Salicylic acid derivatives 101 were converted with ethyl chloroformate and triethylamine followed by reaction with sodium into the corresponding acyl azides 102. The reason for this is because water was not travelling all around the reflux tube as there were residue particles inside it. This result could have been due to errors when carrying out the procedure in the lab as mentioned before.

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