The blue people of troublesome creek. Blue_People_of_Troublesome_Creek 2022-12-29
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The Blue People of Troublesome Creek is a rare genetic condition that results in the affected individuals having blue-tinted skin. The condition is caused by a deficiency in the enzyme responsible for breaking down methemoglobin, a form of hemoglobin that carries oxygen in the blood. When the body is unable to break down methemoglobin, it accumulates in the blood and gives the skin a bluish tint.
The Blue People of Troublesome Creek were a family living in the Appalachian Mountains of Kentucky in the early 20th century. The family's blue skin was passed down through the maternal line, and several generations of the family were affected by the condition. The family lived in isolation in the mountains and were not discovered by the outside world until the 1930s.
The condition that caused the blue skin of the Blue People of Troublesome Creek is now known as methemoglobinemia, and it is a rare genetic disorder that affects only a small number of people worldwide. It is caused by a deficiency in the enzyme that breaks down methemoglobin, which results in the accumulation of methemoglobin in the blood. The condition is usually inherited and is caused by mutations in the gene that codes for the enzyme.
Symptoms of methemoglobinemia include a blue or grey tint to the skin, shortness of breath, fatigue, and a rapid heart rate. The condition can be treated with medications that help the body break down methemoglobin and increase the oxygen levels in the blood. However, if left untreated, methemoglobinemia can lead to serious health problems and even death.
The Blue People of Troublesome Creek were a fascinating and mysterious group of people who lived in isolation in the Appalachian Mountains. Their rare genetic condition gave them a unique appearance that set them apart from the rest of the world. Today, methemoglobinemia is a rare but treatable genetic disorder that affects only a small number of people. Despite the advances in medicine that have allowed for the treatment of methemoglobinemia, the Blue People of Troublesome Creek will always be remembered as a reminder of the mysteries of genetics and the human body.
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When Benjamin was born with purple skin, his relatives told the perplexed doctors about his great grandmother Luna Fugate. Many of these people have high hemoglobin levels because they try to increase their production of red blood cells to replace the limited oxygen supply. Mary Fugate said that the gene is very dominant in the Smith line but there is still no concrete answers as to what couple started the shades of blue people. Her name was Ruth Pendergrass, and she had been trying to stir up medical interest in the blue people ever since a dark blue woman walked into the county health department one bitterly cold afternoon and asked for a blood test. The Fugates were no longer blue. She looked like she was having a heart attack.
Still, others were blue only on their hands or fingernails. Denzil said she never considered legal action. All lived in isolation from the world, bunched in log cabins up and down the hollows, and so it was only natural that a boy married the girl next door, even if she had the same last name. I love pulling in real life examples into every aspect of biology class, simply because it makes things more interesting. The first thing I asked myself after I confirmed that it was real was how the heck have I not heard of this before? All lived in isolation from the world, bunched in log cabins up and down the hollows, and so it was only natural that a boy married the girl next door, even if she had the same last name. I looked at other enzymes and nothing was wrong with them. Stacy counts Fugate blood in his own veins.
Many original settlers gradually began moving out of the area in the 1930s. Most of them old people went by that name the blue Fugates. His two room log cabin sits in the middle of Laurel Fork Hollow. Such people tend to be very blue only at birth, probably because newborns normally have smaller amounts of diaphorase. For some, though, there was a pain not seen in lab tests. Sometime around 1820, a French orphan named Martin Fugate, carrier of an incredibly rare recessive gene for a disease known as hereditary methemoglobinemia, settled on the banks of Troublesome Creek in Eastern Kentucky and married Elizabeth Smith, carrier of the same incredibly rare recessive gene.
Others saw it as a racial issue. Cawein got lucky when a brother and sister named Patrick and Rachel Ritchie walked into a Hazard County clinic. One of the children of Martin and Elizabeth married the stories varied depending on the source , either his sister or his aunt. Normally diaphorase converts methemoglobin back to hemoglobin. Cawein would drive back and forth between Lexington and Hazard an eight-hour ordeal before the tollway was built and scour the hills looking for the blue people he'd heard rumors about.
Sometimes they married first cousins. Over time, fewer and fewer babies were born blue, and those who were took a methylene blue pill once a day to put the pink back in their cheeks. Note: In this instance the reason for cyanosis was not methemoglobinemia but Rh incompatibility. Blue People Family History Resources Faris, David. Luna is buried at the top of the hollow.
Scott's research had found hereditary methemoglobinemia among Alaskan Eskimos and Indians caused by an absence of the enzyme diaphorase from their red blood cells. The search for blue people ensued. This further perpetuated the recessive gene. There was always speculation in the hollows about what made the blue people blue: heart disease, a lung disorder, the possibility proposed by one old-timer that "their blood is just a little closer to their skin. Bewnjamin Stacy is one of the last of the blue Fugates. For the condition to exist in a child, both parents had to be carriers of the gene.
As coal mining and the railroads brought progress to Kentucky, the blue Fugates started moving out of their communities and marrying other people. Tracing Blue People Ancestry Cawein was determined to find a cause and possibly a solution to help this small group of isolated Appalachian people. BOOK WOMAN Chpt 13 Pg 109-111 Hillman Frazier goes missing after he attacks librarian. She was as blue a woman as I ever saw. Cawein advised giving the child methylene blue and not worrying about it. In July 2017, she sent a finished manuscript to her agent, Stacy Testa. They had seven kids and lived happily ever after.
The Science Behind The Mysterious Blue People Of Kentucky
Blue People of Kentucky THE BLUE PEOPLE OF TROUBLESOME CREEK The story of an Appalachian malady, an inquisitive doctor, and a paradoxical cure. He found references to methemoglobinemia dating to the turn of the century, but it wasn't until he came across E. After some further research I discovered it was a genetic condition, and I knew I had to incorporate it into my classroom somehow. Now the question was what exactly caused their skin to be blue? They lived in isolation and married the girl next door, even if they had the same last name, and consequently passed the gene on to many generations. Neither the author nor anyone at Pamela Dorman Books has ever read The Book Woman of Troublesome Creek. . In the history of the packhorse librarian a black librarian was never hired THE GIVER OF STARS Chpt 5 Pg 86, Chpt 28, Pg 384 Introduction of Sophie, who is a smart, strong, blackwho becomes part of the packhorse project.
From a history of Perry County and some Fugate family Bibles listing ancestors, Cawein has constructed a fairly complete story. Little did they know that their union would create shades of blue people! ThenDr Madison Cawein arrived in the sixties. Others thought the family was touched. That was the pain of being blue in a world that is mostly shades of white to black. If you stayed awake in high-school biology, you might remember that Oxygen, or a lack of oxygen, is what turns the blood from red to blue in people with methemoglobinemia. If this conversion continued, all the body's hemoglobin would eventually be rendered useless. If the condition were inherited as a recessive trait, it would appear most often in an inbred line.
This information supplied by John Graves whose uncle was the father of the child. You can tie it into evolution, too! It is documented that Fugates were born in the colonies in the mid 1600's but the original progenitor has not been confirmed. The strain of inherited blue began to disappear as the recessive gene spread to families where it was unlikely to be paired with a similar gene. Baltimore: Gateway Press 1986. Margery is taken aback at the many well-wishers. He had heard rumors of the blue people of Kentucky and recruited a nurse called Ruth Pendergrass to help him in his investigations.
